dependence. In EAs, this genome-wide significant SNP (rs1890881) is in perfect LD with rs61826952 which was genome-wide significant in the COGA GWAS of DSM-IV alcohol dependence (COGA EA+AA p=8.4E-11; see accompanying paper by Lai et al.). The r2 in the AFR reference populations is 0.48, potentially indicating an independent signal in the AAs. However, conditional analyses did not support an effect of rs61826952, independent of rs1890881, on ANYDEP (Supplemental Figures 5D and 5E). Similarly, rs1890881 was not associated with alcohol dependence (Lai et al., accompanying paper), independent of rs61826952 (AA p=0.118; EA p=0.559).
