The final QC’ed dataset consists of 1709 participants of European ancestry from the Affy 6.0 platform and 384 participants from the Illumina platform. Using Beagle software (version: 3.3.2) and the 1000 Genomes Project (2011, Phase 1b data freeze) as a reference, dosage data were imputed on>35 million SNPs for all genotyped samples who passed QC. We performed imputation separately for each genotyping platform. After removing SNPs with a MAF<0.01 or an imputation quality info score<0.3, approximately 7.5 million SNPs remained to analyze. Further information regarding genotyping and imputation can be found in previous publications17,18.
