ADH1B*2 alleles (2.05 vs. 3.15, Tukey HSD p = .004); the difference between those with one versus no ADH1B*2 alleles approached but did not reach significance for SRE_5 (2.32 vs. 5.15, Tukey HSD p =.050). Thus, only a few of the stratified comparisons yielded significant differences across genotypes, but it can be seen from Table 2 that there is a consistent trend in both total symptoms and SRE_5 across the ALDH2-ADH1B genotype combinations. As the number of variant alleles increases for both genes, the total symptoms score increases and the SRE_5 score decreases, indicating increased sensitivity to alcohol at low levels of consumption and during initial lifetime consumption for individuals who possess either variant allele.
