to months) in vivo; (3) It is most prominent in regions of the brain that are strongly implicated in learning and memory (e.g. neocortex and hippocampus); (4) LTP is specific to tetanized inputs: the non-tetanized inputs are not potentiated; (5) LTP has Hebbian-like properties, in that it requires conjoint pre-and post-synaptic activity for its generation; (6) There is the requirement for cooperativity amongst afferent fibers to induce LTP; (7) Associativity amongst afferents can also be demonstrated, i.e. a tetanus too weak to elicit LTP will do so, if paired with a strong tetanus; (8) Drug treatments that selectively block the induction of LTP also selectively impair learning and memory [6–9]. It is important to note that these conceptualizations are historical and that more recent work has determined that there are exceptions to these rules [10, 11].
