and actin dynamics. Genes governing circadian rhythms were over-represented among the few genes that were affected in the nucleus accumbens under both conditions. Interestingly, while the nucleus accumbens of C57Bl/6J mice was more responsive than prefrontal cortex to an acute ethanol challenge [54], an opposite pattern was found following chronic intermittent exposure to ethanol both in Wistar rats [31] and in C57Bl/6J mice [30], suggesting that tolerance to transcriptional disruption develops in the nucleus accumbens over the course of ethanol exposure, while the prefrontal cortex gets recruited later on in the process of ethanol dependence.
