trait locus (eQTL) in monocytes (Zeller et al. 2010), as reported on an eQTL browser (http://eqtl.uchicago.edu/). The variant rs1579695 (p=1.12 × 10−5) identified in the present study was also found to be a potential cis eQTL in monocytes as shown in the data of Zeller and colleagues (Zeller et al. 2010). This gene also showed nominal significance with maxdrinks in gene-based association analysis performed using VEGAS (p = 4.13 × 10−4). Variants identified in the present study remained significant even after controlling for ADH1B SNP, which shows that these genes have independent effects on alcohol consumption.
