To identify sets of causal variants, we fine-mapped each of the 27 genome-wide loci using three fine-mapping tools, FINEMAP v. 1.3.1 (ref. 75), PAINTOR v.3.0 (ref. 76) and CAVIARBF v.0.2.1 (ref. 77), using CAUSALdb-finemapping-pip downloaded from https://github.com/mulinlab/CAUSALdb-finemapping-pip78. Since no secondary lead variants remained genome-wide significant after conditional analyses, one causal variant was assumed per locus. Variants located in a region of 1 Mb around index variants were included in the analyses. We used a threshold of 95% for the total posterior probability of the variants included in the credible sets, and only variants claimed to be within the set by all three methods were included in the final credible set for each locus.
