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Chunk #9 — Results and Discussion — Methods for calculating power with heritability in one-degree-of-freedom models

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GWAPower: a statistical power calculation software for genome-wide association studies with quantitative traits.
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It should be noted that (1) the absolute values of SST and SSM are unknown, as are the absolute values of numerator and denominator of the t-statistic. However, in this approach, only the relative values are necessary to calculate power; (2) the t-test is associated with the ANOVA table. In this study, an ANOVA (and the associated F-test) is used owing to its ability to accommodate the concept of heritability and to adjust for covariate effects. Therefore, if a dominant or a recessive genetic model is considered, the t-test compares two sample means within an ANOVA framework, although an ANOVA t-test is different from a "two sample t-test".