qEEG abnormalities and impaired functioning on complex cognitive tests in patients formerly dependent on cocaine might not be proximately caused by drug use per se but be more related to comorbid alcohol use or another psychiatric condition. Taken together, the findings converge on the conclusion that there exists an inherited predisposition for an externalizing psychopathology that includes ADHD, conduct disorder, and substance abuse. PTSD seems to heighten the risk for addiction as well. Thus, the reviewed findings support the hypothesis that addicted subjects may manifest a P300 amplitude reduction and qEEG abnormalities as a trait reflecting the CNS disinhibition, which may be a predisposing factor for addiction liability, resistance to drug habit extinction, and relapse vulnerability.
