MRIs were collected on a 3.0T Siemens Trio Tim platform, located at the Queens Medical Center in Honolulu, HI. For each subject, we acquired a sagittal T1-weighted (MPRAGE) image (TR = 2200 ms, TE = 4.1 ms, TI = 1000 ms, acquisition matrix = 256 × 256) with 160 slices at 1.0 mm thickness and a Fluid Attenuated Inversion Recovery (FLAIR) image (TR = 9100 ms, TE = 83 ms, TI = 2500 ms, acquisition matrix = 204 × 230) with 44 slices at 3 mm thickness. A neuroradiologist read all MRI scans. All scans were free from abnormalities other than white matter signal hyperintensities (WMSH) visualized on the FLAIR images. Subcortical hyperintensities were identified on only a handful of subjects in the current study samples.
