Chunk #34 — Discussion

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Resource profile and user guide of the Polygenic Index Repository.

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We described the initial release of the Polygenic Index Repository, which contains PGIs for 47 phenotypes. A major goal of this effort is to disseminate PGIs with greater predictive power than the PGIs typically used. To maximize prediction accuracy of the PGIs, we meta-analysed data from multiple sources, including 23andMe and the UK Biobank.