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Chunk #51 — INTEGRATION OF EPIGENETIC CHARACTERIZATION INTO EXISTING HUMAN RESEARCH PARADIGMS

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The epigenetics of maternal cigarette smoking during pregnancy and effects on child development.
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Preliminary evidence already points to important genetic differences in xenobiotic metabolism with downstream impacts on intrauterine growth (Price, Grosser, Plomin, & Jaffee, 2010) and behavior (Knopik, McGeary, Nugent, Francazio, & Heath, in press) Further characterization of these samples from an epigenetic standpoint could explain additional variance in behavioral outcomes while simultaneously identifying potentially targetable mechanisms to reduce such impacts.