overall model it still demonstrates significant predictive utility for questions of basic science and, potentially, even those related to clinical issues (e.g., novel molecular targets). For example, studies reporting associations between amygdala reactivity and 5-HTTLPR genotype have accounted for similar percentages of variance (47); given that those findings have been shown to have clinical relevance (48), the small effects reported here may as well. Moreover, it is possible that even small differences in how the amygdala processes information result in a cascade of neural, hormonal, and physiological changes that affect behavior and clinical risk; such small effects may be particularly pertinent in the context of cellular and nuclear receptors in the HPA axis, which can act as transcription factors to widely influence gene expression (49).
