Marker-wise significance test was performed in order to assess the allelic distribution in pair-wise comparison of studied cohorts (CEU sample was not included) (Table 2). After applying Bonferroni correction (based on 273,464 markers which equals with the p<1.8×10−7) 48 out of 171 of those modeled case-control association analysis between current populations did not reveal any significant hits. Although, in total 16,240 significant hits were identified, while the highest number was 1,620 between Kuusamo and Spain (if Finnish and Italian samples were left out, only comparison with Spanish sample revealed more than 100 markers in single comparison). The average number was 90.4 SNPs and after exclusion of outliers comprising Southern Italy, Kuusamo, Northern Italy and Helsinki data (as the number of significant SNPs was times higher when comparison with Italian and Finnish cohorts) the average decreased to 80.0; 23.0; 21.1 and 10.1 SNPs, respectively. The total number of loci that had a “significant SNP” was 2,263. In order to decrease the amount of loci and identify the meaningful hits, only the loci which had at least two significant hits in at
