2010]. Notably, bin B is also associated with mRNA levels of CHRNA5 in brain and lung [Falvella, et al. 2010; Smith, et al. 2010; Wang, et al. 2009]. Bin C, tagged by rs6495308 [Liu, et al. 2010], rs2036534 [Thorgeirsson, et al. 2010], rs7163730, rs9788682, rs684513 [TAG 2010], and rs578776 [Saccone, et al. 2010], is associated with heavy smoking after conditioning on bin A (p values from 9.1×10−5 to 6.3×10−9). In contrast to bin B, bin C is less significant in conditional analysis compared to single SNP analysis. Bin D is represented by rs2869046, which also displayed residual association after conditioning on bin A (p=4.8×10−5) [Thorgeirsson, et al. 2010]. Markers from these different bins (A, B, C, and D) are only modestly correlated with one another, with r2≤0.52 in the 1000 Genomes Pilot 1 CEU (N=180; Table 2).
