a lesser degree, loss of small-worldliness and lower levels of synchronization within high frequency EEG rhythms (beta and gamma) has also been reported in normal aging (Micheloyannis et al., 2009). As another example, in patients presenting after a first seizure, mean functional connectivity within the theta band has been reported to be a predictor of subsequent epilepsy, and thus may prove useful in identifying patients at risk for epilepsy who lack other markers such as epileptic spikes (Douw et al., 2010). Enhanced fcEEG across a broad range of frequencies has also been suggested as a characteristic feature within the seizure onset zone in patients with mesial temporal lobe epilepsy (Bettus et al., 2008).
