filter), G-loop and M2 gates, and the cytoplasmic interaction sites (Figure 2A). Notably, these crystals revealed two different positions of the G loop, which have been tentatively ascribed to putative open and closed states of the channel72. Though more studies are needed, a structural view of GIRK channel gating is emerging that involves the N-terminal slide-helix73, K+ and polyamine binding sites69,70,71,74, and movement of the M2 and G loop gates65,69,71,72,73.
