spanning the GABRA2 region including several SNPs that have been consistently associated with AD (Covault et al., 2004; Covault et al., 2008; Enoch et al., 2009; Fehr et al., 2006; Lappalainen et al., 2005), which allowed for a comprehensive examination of GABRA2 SNPs on subjective responses to alcohol. Furthermore, the number of subjects who participated in our study is relatively large compared to other studies (Pierucci-Lagha et al., 2005), which provided the statistical power necessary to examine a larger group of SNPs. In addition, we were very stringent in setting significance levels. Importantly, we estimated genetic ancestry proportions for each subject to identify population substructure within our sample, and ancestries were adjusted for in the SNP and haplotype association analyses.
