Comorbid alcohol and substance dependence (including cocaine, stimulant, sedative, and opioid dependence) occur more frequently among comorbid bipolar I and II individuals (see Table 6) and resemble diagnostic rates obtained at baseline. Further, members of Groups 1, 3, and 4 developed depressive episodes more frequently, and bipolar I individuals reported more panic attacks. Non-comorbid bipolar I patients (Group 3) reported a higher number of suicide attempts. Rates of other comorbid mental disorders also mainly replicated those from the baseline assessments. Significant differences were found for higher PTSD rates in comorbid bipolar I subjects across groups. Reports of affective symptoms during the follow-up interview were highest in Group 4 (bipolar I and CUD) individuals. Comorbid bipolar I and II individuals had significantly lower GAF scores than Group 1 and 3 individuals.
