Autti-Ramo et al. applied image analyses to structural MRI and studied the brain morphological alterations caused by PEA. Out of the 17 children with PEA in this study, hypoplasia of the vermis was observed in 10 children and one had malformed posterior vermis. Five children had hypoplastic cerebellar hemispheres. Hypoplasia of the corpus callosum was observed in two children. Small hippocampi were observed in three children and wide cortical sulci in six. No particular structural anomaly correlated specifically with neuropsychological deficits, but abnormal development of cerebellar vermis was found the most sensitive morphological indicator for PEA effects141.
