or cut back on important activities in order to drink’), and thus, the hypothesis of underlying genetic homogeneity cannot be fully rejected. However, it is possible that the ability to localize genetic loci for AUDs is likely to be reduced when using scoring methods that ignore the fact that symptoms are influenced by shared and non-shared genetic factors (i.e., just as there are a multitude of symptom profiles that lead to an AUD diagnosis, the respective genetic risk profiles for these various symptom profiles may vary accordingly).
