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Chunk #27 — SNP heritability and genomic risk profile scoring methods

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Alcohol Dependence Genetics: Lessons Learned From Genome-Wide Association Studies (GWAS) and Post-GWAS Analyses.
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explained only 0.68% of the phenotypic variance, and that the variance explained plateaued at P≤0.01 (17.6%), suggesting that the SNP heritability signal is primarily coming from SNPs with P≤0.01. When they partitioned the genome by chromosome and by genic/intergenic regions to estimate the variance explained by each chromosome/region, they found a relationship between the length of the chromosome and the amount of phenotypic variance explained. However, they found no relationship between the number of known genes on a chromosome and the explained phenotypic variance.