To corroborate our simulation findings, we undertook an analysis of 96 PRSs developed for the prediction of multiple complex traits in European and African ancestry individuals from the UK Biobank, including HbA1c levels, asthma status, and prostate cancer (Table S1). We tested variant selection strategies based on p value thresholding and LD clumping of genome-wide summary statistics15 computed in independent European or African ancestry cohorts and variant weights from the same approaches with an additional weighting from a fixed-effects meta-analysis across populations. Multiple p value thresholds and weighting strategies were tested to assess the PRS accuracy in African ancestry individuals relative to European ancestry individuals across parameters.
