Chunk #6 — Results

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Tobacco smoking is associated with methylation of genes related to coronary artery disease.

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the associations were robust to further adjustment for total cholesterol, triglyceride levels, systolic blood pressure, daily alcohol intake and type 2 diabetes mellitus as potential confounders or mediators. In a sensitivity analysis in current smokers, two sites were significantly associated with cumulative exposure to tobacco smoking (Table 3).Table 2Significant associations between tobacco smoking and methylation of CAD genesCurrent-NeverAdjusted modelCurrent-FormerAdjusted modelCpG siteEstimate (se) p-valueEstimate (se) p-valueEstimate (se) p-valueEstimate (se) p-valuecg24908166−0.014 (0.003)1.1 × 10−7 −0.015 (0.003)1.6 × 10−8 −0.006 (0.002)0.02−0.007 (0.003)0.01cg12324353−0.012 (0.003)1.3 × 10−7 −0.012 (0.002)3.5 × 10−7 −0.007 (0.002)2.8 × 10−3 −0.007 (0.002)2.1 × 10−3 cg03725309−0.024 (0.005)2.0 × 10−7 −0.022 (0.005)3.8 × 10−6 −0.017 (0.004)4.2 × 10−5 −0.016 (0.004)1.2 × 10−4 cg00980784−0.015 (0.003)2.5 × 10−7 −0.014 (0.003)3.5 × 10−6 −0.015 (0.003)2.4 × 10−8 −0.015 (0.003)8.6 × 10−8 cg13916835−0.021 (0.004)3.0 × 10−7 −0.021 (0.004)1.3 × 10−6 −0.013 (0.004)1.5 × 10−3 −0.013 (0.004)1.9 × 10−3 cg09469355−0.017 (0.003)7.7 × 10−7 −0.017 (0.003)8.5 × 10−7 −0.015 (0.003)3.8 × 10−6 −0.015 (0.003)1.6 × 10−6 cg05603985−0.014 (0.003)8.4 × 10−7 −0.013 (0.003)3.6 × 10−5 −0.014 (0.003)1.3 × 10−7 −0.014 (0.003)2.4 × 10−7 cg04324276−0.015 (0.003)3.2 × 10−6 −0.015 (0.003)1.2 × 10−5 −0.010 (0.003)2.4 × 10−4 −0.010 (0.003)5.2 × 10−4 cg25468516−0.015 (0.003)3.6 × 10−6 −0.014 (0.003)3.0 × 10−5 0.011 (0.003)2.3