in oligodendrocytes that were decreased in the vHip (86%) compared to 79% overall, although only suggestive (p=0.09), may hint at a relative decrease in the number or activity of these critical cells. Previous work showed that expression of genes responsible for serotonin production and signaling, also required for neurogenesis (Brezun & Daszuta, 1999), were greatly decreased in the DRN of these animals (McClintick et al., 2015). The decreased Wnt signaling in the hippocampus, combined with the lower serotonin input from the DRN, together would be expected to reduce neurogenesis in the vHip. Reduced neurogenesis would likely result in retarded development of the vHip, and potentially produce long-term consequences on learning and memory in adulthood; however, these animals were not tested for effects on memory.
