We identified a further 21 loci with suggestive (5 × 10−8<p<5 × 10−7) evidence of association with FEV1 extremes (appendix pp 72–73), including six rare variants with a minor allele count less than 400. These included signals in CCDC91 and RSRC1, both of which showed genome-wide significant association with lung function in an independent concurrent study of lung function in the general population.35
