The ISC was the first to demonstrate the utility of testing polygenic scores [3]. In their main result, odds ratios for 74062 nearly independent SNPs were estimated in 3322 cases and 3587 controls and used to construct a polygenic score that was tested in 2687 cases and 2656 controls of the Molecular Genetics of Schizophrenia study [26]. The score was more strongly associated as higher P-value thresholds were used for including SNPs, with the most significant reported association having with an inclusion threshold of .
