In summary, this study provides the first set of data on cross-generational epigenomic alterations associated with THC exposure in the rat NAc, including DMRs localized to genes with important roles in neural function, complex psychiatric diseases, and addiction-related traits. Future work will require more rigorous comparisons between epigenomic and transcriptome alterations in order to address the mechanistic implications of these findings. The knowledge emerging from such investigations will likely contribute to the understanding of the heritability of epigenetic marks in relation to the consequences of parental THC exposure.
