In the CA1 sector of a 13-year-old male, several areas of dysplastic changes with a significant deficit of pyramidal neurons without gliosis were found (Fig. 3g). In affected areas, the size and shape of neurons varied over a wide range. Pyramidal neurons were very rare, whereas small irregular or oval-shaped, poorly differentiated neurons prevailed (Fig. 3h). In the dysplastic area in the CA1 sector of the 56-year-old autistic subject, an opposite trend was present, with thickening of the pyramidal layer and an increased packing of dysplastic neurons (not shown).
