The present review discusses personalized treatment of AUD and considers genetic variation as a predictor of clinical response to pharmacotherapy for AUD. While we acknowledge that pharmacogenetics can also affect response to alcohol itself, the literature on genetics of alcohol response is beyond the scope of this review and is discussed elsewhere in this special issue and in previously published reports (for review see16). Specifically, we focused the present review on studies assessing the effect of gene variants on AUD treatment response among diverse ancestries. We begin with a discussion of health disparities in treatments for AUD, then review the existing studies of pharmacogenetics of treatment response in alcoholism among individuals of diverse ancestries, and conclude with recommendations for future research in this relatively new era of precision medicine.
