Through a meta-analysis of large numbers of T2D genome-wide scans with additional follow-up within the DIAGRAM consortium (Supplementary Information), allele C of rs231362 was shown to associate with the disease (OR = 1.08, P = 3 × 10−13). Rs231362 is also located in KCNQ1 (Figure 2), but it is not substantially correlated with rs2237892 (r2 = 0.002). Rs231362 is not on any of the Illumina chips used. A training set of 912 haplotypes, created through single track assay genotyping of 228 trios, was used for imputation of rs231362 into the Icelandic samples. Employing the imputed results, the standard case-control test gave an OR of 1.10 (P = 0.013). The effect, however, appears to be limited to the maternally inherited allele (OR = 1.23, P = 6.2 × 10−5).
