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Chunk #28 — Discussions

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Enrichment of cis-regulatory gene expression SNPs and methylation quantitative trait loci among bipolar disorder susceptibility variants.
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We believe that genome-wide association studies of neuropsychiatric phenotypes merit the kind of investigation made possible by the genome-wide maps of mQTLs and eQTLs . Though much of the functionality of mQTLs that do not correlate with eQTLs remains to be elucidated, the effect of genetic variation on methylation suggests an important new area to explore and may provide mechanistic insights into genome-wide association findings.