the corrected estimate for the genotypic effect of AA on depression in the RADIANT/WTCCC2 study with the effects in the previous studies we arrive at an estimate of an OR = 1.398 (95% CI 1.254–1.557) with a combined two-sided p-value of 1.41e-09 (fig. 3). Considering only the replication studies (thus excluding MARS) we have an estimate of 1.315 for the OR (95% CI 1.172 – 1.477) with a two-sided p-value of 3.19e-06.
