also influence alcohol dependence via the glutaminergic pathway that is known to play important roles in alcohol intoxication and withdrawal (64). SERINC2 is enriched with numerous structural variants (see NCBI dbSNP). The three genome-wide significant risk SNPs are also located within CNVs and may thus be functional. Furthermore, SERINC2 is close to four LncRNAs. Eight SNPs within these LncRNAs were associated with alcohol dependence, suggesting an additional potential regulatory pathway for SERINC2 in influencing alcohol dependence.
