stopping smoking and taking medications, an even better solution would be to include questions about suicide in ongoing prospective cohort studies. As many possible confounds, moderators and mediators as possible should be included. This is important not only to better examine causality but also because the incidence and behavioral mechanisms of suicide likely vary between men and women, older and younger persons, those with vs without existing psychiatric illnesses, etc. It would be of special interest to compare rates of suicide in NRT vs non-NRT medications. Also, a systematic search of all published RCTs of treatments for smoking cessation could compare the incidence of mentions of suicide in the active vs control groups; however, given the brief reporting of AEs in most publications, this could produce a false negative.
