In summary, in the last ten years we discovered two critical pathways involving Tcl1 (Figure 2). In T-cells, Tcl1 activates Akt, this leads to increased proliferation, inhibition of apoptosis and T-cell transformation [33]. In B-cells, Tcl1 functions as transcriptional regulator, it activates NF-kB and inhibits AP-1 [23]. This leads to defects in apoptosis, increase in cell survival, and CLL pathogenesis.
