Cortical neural activity is determined by the complex interplay between excitation and inhibition [1, 2]. Distinct populations of specialized neurons originate from different neocortical regions. Excitatory projection neurons originate from cortical progenitors in the pallium [3], whereas the inhibitory interneurons originate in the ganglionic eminence (GE) of the ventral telencephalon [4]. Processes like maturation, neural specification and synapse formation all contribute to normal development of cortical networks [1]. Disruption of the balance between excitatory and inhibitory neuronal activity, leading to disturbances in network synchrony, is thought to underlie neurodevelopmental disorders, such as epilepsy, autism spectrum disorders (ASDs) and schizophrenia [5].
