The results from Experiment 2 suggest that the spectral nature of individual brain network synchronization may be an important consideration when designing personalized interventions aimed at increasing working memory function. The results from Experiment 2 also suggest that a concurrent modulation of prefrontal and temporal regions may be necessary to effectively manipulate the frontotemporal circuit and boost cognitive performance. Future neuroimaging studies combined with HD-tACS will be helpful in clarifying the precise brains areas responsible for these stimulation effects, including whether subcortical regions with nonzero time lag (perhaps remotely activated by stimulation) interact with prefrontal and temporal areas to facilitate changes in memory performance.
