factor in conducting enrichment studies. We are confident that failure to adequately account for LD will not affect our estimate of the proportion of SNPs that are eQTLs, but rather the variance of this estimate. There are, however, more subtle biases related to LD that might have affected our studies. For example, true associations may be more easily detected in regions of the genome with high LD because these regions are more likely to have good coverage on high throughput platforms for GWAS. Although it is unclear that this would bias results of our studies, it is important to note that these types of subtle biases can affect results of enrichment studies in unpredictable ways.
