of the SNPs (rs925488, rs1877431, rs1588635) detected in the VIVA cohort was also reported by Lowe et.al (38); there was no overlap with Medici et al (43). Also, three of the SNPs (rs2805809, rs2668804, rs2808693) reported by Lowe et al. (38) was in high linkage disequilibrium (1.00) with rs2805771, rs2808699, rs7875482 detected in the VIVA cohort. This is a region of high LD, located in the 5′UTR-region of the gene which has been shown to influence transcriptional regulation of FOXE1(TTF-2). The functional variant is likely to be situated at this locus, but its exact localization remains to be elucidated in future studies, involving in-depth resequencing.
