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Chunk #9 — Impact of measurement error

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Endophenotype: a conceptual analysis.
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We can best illustrate this point using path models. Assume, for example, the mediational model for EP as depicted in Figure 1b. As pictured, as long as EP is not perfectly correlated with PD (that is, the standardized path from EP to PD is < |1.00|), it is logically necessary that the genetic effect will be stronger on EP than on PD. However, this model ignores measurement error.