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Chunk #12 — Methods — Computational haplotype-based genetic mapping

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From mouse to man: the 5-HT3 receptor modulates physical dependence on opioid narcotics.
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The phenotypic data were evaluated using the average value for each strain, obtained by assessing eight mice per strain. The haplotype blocks are then ranked based upon the calculated P value. When this computational analysis was performed, the haplotype map had 5694 haplotype blocks generated from 215 155 single nucleotide polymorphisms (SNPs) characterized across 19 inbred strains covering 2609 genes. From this analysis, the candidate haplotype blocks empirically selected for further analysis had the best P values.