The primary GWAS meta-analysis consisted of four European ancestry (EU) GWAS datasets: 1) 969 cases and 3,923 ancestry-matched controls from the initial Tourette syndrome GWAS (GWAS1) (9); 2) 2,711 additional EU ancestry Tourette cases (4) and 3,762 ancestry-matched controls (GWAS2); 3) Tourette probands from GWAS1 and one or more of their Tourette syndrome-affected family members (10) (N=548) plus 597 ancestry-matched controls (GWAS2 FAM); 4) 591 independent EU Tourette probands from the TIC Genetics consortium (TIC)(11) and 1,206 unselected ancestry-matched controls. Genotyping details are provided in the online Data Supplement (Tables S1 and S2).
