Selection of control families was based on availability of a pair of same sex adult siblings. Selection of families was based on one of two methods. In the first method (Control Group I – CPFFS Study), volunteers were screened for Axis I psychopathology including alcohol and drug dependence using the DIS. Control families were selected if the volunteer’s first-degree relatives (parents and siblings) were similarly free of psychopathology. In the second method (Control Group II – BRFFS Study), volunteers from the same census tract who indicated they had children between the ages of 8–18 years were screened as a potential control family in order to match the family to a high-risk family using census tract information. The control parents of these offspring were screened for parental alcohol or drug dependence. Comparison of control groups I and II did not reveal significant differences in socioeconomic status (mean SES = 44.22 ± 11.8 SD for the CPFFS controls and mean = 45.99 ± 11.66 for the BRFFS controls), or in offspring rates of psychopathology in the two control groups (rates of “any”
