Full pathway analyses are in Supplementary Table 11, and 19 pathways with false discovery rate q-values < 0.05 are summarized in Fig. 4. The major groupings of significant pathways were: RBFOX1, RBFOX2, RBFOX3, or CELF4 regulatory networks; genes whose mRNAs are bound by FMRP; synaptic genes; genes involved in neuronal morphogenesis; genes involved in neuron projection; genes associated with schizophrenia (at P<10−4)19; genes involved in CNS neuron differentiation; genes encoding voltage-gated calcium channels; genes involved in cytokine and immune response; and genes known to bind to the retinoid X receptor. Several of these pathways are implicated by GWA of schizophrenia and by rare exonic variation of schizophrenia and autism56,57, and immediately suggest shared biological mechanisms across these disorders.
