were many gene expression differences associated with age (e.g., in astrocytes, 1908 age-associated genes were identified with FDR < 0.05; age, ethnic origin, and AUD status as covariates). However, since the AUD and non-AUD groups were age-matched (AUD average age = 54.9; non-AUD average age = 56.7) and age was included as a covariate in the above analyses, this does not impact our ability to identify patterns of expression and chromatin differences associated with AUD.
