Joubert et al. [2009] used a novel variance component method for the estimation of age-dependent genetic effects on longitudinal SBP using 57,837 SNPs on chromosomes 17–22 genotyped in the Offspring Cohort. Three SNPs reached genome-wide statistical significance for association with longitudinal SBP using a Bonferroni corrected p-value of 8.6×10−7. Of these three SNPs, one corresponded to the main genetic effects, and the remaining two were for the 2 degrees of freedom (df) test, which simultaneously estimated the main genetic effect and genotype×age interactions for each SNP. There were no significant genotype×age interactions for SBP in these data.
