In the previous PAU study9, the rg between MVP AUD and PGC AD was 0.98, which justified the meta-analysis of AUD (includes AUD and AD) across the two datasets, and the rg between AUD and UKB AUDIT–P was 0.71, which justified the proxy-phenotype meta-analysis of PAU (including AUD, AD and AUDIT–P) across all datasets. In this study, we use the same definitions, defining AUD by meta-analyzing AUD and AD across all datasets, and defining PAU by meta-analyzing AUD, AD and AUDIT–P (Table 1). No statistical method was used to predetermine sample size.
