Chunk #7 — Materials and methods — Collaborative Genetic Study of Nicotine Dependence data

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Uncovering hidden variance: pair-wise SNP analysis accounts for additional variance in nicotine dependence.

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All genotype data have undergone extensive quality control measures (Bierut et al. 2007; Saccone et al. 2009a). Self-reported race was verified with an EIGENSTRAT (Price et al. 2006) analysis including HapMap data. EIGENSTRAT analysis also found no significant population differences between sites. Map positions and annotations were obtained from the Genome Reference Consortium Homo sapiens assembly GRCh37.