we accounted for the correlation in our multiple testing procedures. Furthermore, a slight level of redundancy in SNP coverage allowed for a more stringent criteria for the removal of SNPs with low call rates, resulting in 97% of the analyzed SNPs having call rates >95%. SNPs with low call rates were driven mostly by genotyping failures for individuals with whole genome-amplified DNA for that particular SNP only. Thus, when there was a discrepancy between call rates for individuals with genomic DNA and individuals with WGA DNA, we limited our analysis to only those individuals with genomic DNA. Finally, for the top SNP rs2072661, there was a 97% concordance between the genotypes obtained from the Illumina assay versus genotypes obtained using TaqMan® (Applied Biosystems, Foster City, CA, USA) assay (data not shown). When we compared carriers versus non-carriers, i.e. a dominant model, we observed 100% concordance.
